In 2046, Earth is a new planet. New rules govern it. After more than thirty years after the arrival of various strangers on its surface, the landscape has been almost completely changed and strongly transformed beyond recognition. To the city of Defiance, formerly called St. Louis, comes the mysterious Nolan (Grant Bowler) and his subordinate Irisa (Stephanie Leonidas). As soon as the heroes settle in a city supervised by the mayor Amanda Rosewater (Julie Benz), inhabited by people like influential Rafe McCawley (Graham Greene), entrepreneurial owner of the salon Kenia (Mia Kirshner) and ambitious strangers - Tarrs (Tony Curran and Jaime Murray) - the development of events begins to threaten the impermanent peace for which this border city fought.